Bioanalysis

A Simple, Reliable and Rapid LC-MS/MS Method for Simultaneous Determination of Carbamazepine and Carbamazepine-10,11-epoxide in Human Plasma - April, 2014

Carbamazepine is one of the most often used anticonvulsant and mood-stabilizing drugs. It is primarily used in the treatment of epilepsy and bipolar disorder.

Carbamazepine-10,11-epoxide is known as a primary active metabolite of  Carbamazepine and the presence of this “epoxide” metabolite can have clinically significant implications in therapeutic drug monitoring of carbamazepine. However, traditional methods such as immunoassays, GC-MS and mathematical conversions are low-throughput and less accurate.

Therefore, it is highly desirable to have a simple, reliable, rapid, and accurate bioanalytical method for simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide, which is essential for high sample throughput applications. The following poster abstract outlines the development and validation of liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for determination of carbamazepine and carbamazepine-10,11-epoxide in human plasma.

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