Neuropharmacology

Powerful Amyloid Staining Options at QPS - February, 2014

The deposition of amyloid-β (Aβ) peptide plaques in the brain is a central feature of Alzheimer’s disease (AD) pathology. In transgenic mice overexpressing the human amyloid precursor protein (APP), the pattern of Aβ deposition is similar to that seen in humans with AD.

While Alzheimer himself relied on iodine stains to detect amylum (starch), it was later discovered that amyloid deposits can be visualized with polarized light and exhibit birefringence when labeled with Congored. Nowadays, total mature amyloid plaque staining options can be selected in accordance with the treatment target. These techniques can also be readily combined with other methods for detecting hallmark pathologies, such as phosphorylated Tau or synaptic markers indicating neuroinflammation.

Click here to find out more about QPS' powerful amyloid staining options.

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