Neuropharmacology

QPS Austria Scientists Publish on APPSL Mice as In Vivo Models for Alzheimer’s Disease

Beyond cognitive decline, Alzheimer’s disease (AD) is characterized by numerous neuropathological changes in the brain. Although animal models generally do not fully reflect the broad spectrum of disease-specific alterations, the APPSL mouse model is well known to display early plaque formation and to exhibit spatial learning and memory deficits. However, important neuropathological features, such as neuroinflammation and lipid peroxidation, and their progression over age, have not yet been described in this AD mouse model.

The present study illustrates for the first time the progressive increase in AD-specific biochemical hallmarks in APPSL mice, including profoundly increased soluble and insoluble Aβ40 and Aβ42 levels, aggregated Aβ, fibrillar Aβ, lipid peroxidation, and astro- as well as microgliosis in the hippocampus and neocortex, up to an age of 12 months. Correlation analyses reveal a highly significant correlation between the severity of neuroinflammation and Aβ, fibrillar Aβ and lipid peroxidation levels.

Together with previously published data on progressive cognitive decline, the current study shows that the behavioral and neuropathological profile of APPSL mice closely mimics that of AD patients. This relationship may help to further elucidate the complex association of pathological factors in the disease.

Please access the original article here, co-authored by Tina Löffler, Stefanie Flunkert, Daniel Havas, Cornelia Schweinzer, and Birgit Hutter-Paier of QPS Austria.

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