Neuropharmacology

Arterial Diameter Progressively increases in Mutant AD Mice - a Comparative Study to Human AD Cases - April, 2014

Changes of gross vascular morphology were reported for different mouse models of Alzheimer’s disease (AD) and for human AD cases. Those changes comprise cerebral amyloid angiopathy (CAA) but also increased IR area of vascular markers. The latter was interpreted as vascular sprouting and/or increase of vascular diameter. However, this interpretation is critical within two respects:

  • Sprouting or diameter alterations are two totally different mechanisms to increase blood flow as a reaction to lacking nourishment as found in AD. Thus it is important to figure out, which one exactly is responsible for increased vascular marker signal.
  • The translation ability of findings in mouse models to human cases has to be investigated.

In this poster abstract, we present the observed effects on vascular lumen in APPSL mice paired with increased vascular amyloid plaque size.

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