Neuropharmacology

Tau Phosphorylation - A Hot Topic in CNS Research - April, 2014

Tau proteins stabilize microtubules in neurons of the central nervous system. Abnormal phosphorylation of Tau protein is a key feature in a cluster of neurodegenerative diseases, including Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS), Niemann Pick Disease and of course, Tauopathies. When Tau becomes hyperphosphorylated, it leads to conformational changes in Tau assembly and subsequent formation of paired helical filaments (PHF), which is typically also accompanied by protein truncation. PHFs inhibit the proper function of neurons, as they interrupt the transport of elementary proteins within the cell. This blockade leads to severe neuronal dysfunction and finally, dementia; it is believed to have an even higher impact on memory loss in AD than the amyloid load.

Click here to find out about the ever widening variety of disease-related phospho-sites we can measure to support your CNS investigations.

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