Dinaciclib, a Potent Cyclin-Dependent Kinase Inhibitor, and its Novel Function in Neuronal Development - April, 2014

Cyclin-dependent kinase 5 (Cdk5) is a multifaceted serine/threonine kinase protein playing an essential role in neuronal development. Over the last decade, Cdk5 activity has been demonstrated to regulate such pivotal cellular processes as neuronal migration, neurogenesis or dendritic outgrowth. The aberrant activation of Cdk5 results in hyperphosphorylation of its various substrates, like Amyloid Precursor Protein, Tau protein and neurofilaments and subsequently to neuronal death. Dysfunction of Cdk5 has been associated with diverse neurological disorders including Alzheimer's disease, amyotrophic lateral sclerosis or Niemann-Pick type C disease. Recent evidence also suggests a pivotal role for Cdk5 in synaptic plasticity, behavior, and cognition.

In this poster, we present whether the novel Cdk5 inhibitor Dinaciclib with its known function in advanced malignancies is able to promote neurite outgrowth and neurogenesis in primary rat hippocampal neurons.

20 years in pharma R&D navigation