Neuropharmacology

An Inducible Murine Model of Tau Phosphorylation - August, 2014

Accumulation of hyperphosphorylated Tau protein is characteristic for tauopathies and many other neurodegenerative diseases. The physiological role of Tau in the central nervous system (CNS) is to assemble and stabilize microtubuli, a process that requires a balance between phosphorylation and dephosphorylation.

Hyperphosphorylated Tau has been shown to dissociate from microtubuli, resulting in the breakdown of axonal flow, and thus impairment of neuronal viability and function. Since Tau presents a promising target for e.g. kinase inhibitors, an inducible model of Tau phosphorylation can be a useful tool for studying CNS drug effects.

In this poster, we present how hypothermia induced by pentobarbital administration in mice mimics pathogenic events of neurodegenerative diseases and is thus a useful non-transgenic model to study CNS drug mechanisms.

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