Phase II - IV Clinical

Postoperative Cognitive Dysfunction (POCD)

Postoperative cognitive dysfunction (POCD) is a common problem among elderly people undergoing major surgery and has significant consequences for patients, healthcare systems and society. So far, the pathophysiological mechanisms remain unclear. Dr. Izaak den Daas, Principal Scientist at QPS, and Prof. Anthony Absalom’s research group at the Department of Anesthesiology, University Medical Center Groningen (UMCG), are collaborating closely to study this phenomenon.The investigation will comprise several phases. The first will examine the incidence of POCD within the elder population undergoing surgery at the UMCG. The next will include pre-clinical and clinical studies of the ability of known PET tracers to detect neuronal inflammation. It is our hope that this research will provide insight into how this POCD may be prevented by pharmacological intervention in the future.

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