Clinical Development

Relative bioavailability and food effect of the galectin‑3 inhibitor selvigaltin (GB1211) administered as a tablet in healthy participants (GALBA‑1)

QPS

Relative bioavailability and food effect of the galectin‑3 inhibitor selvigaltin (GB1211) administered as a tablet in healthy participants (GALBA‑1) Read More »

A Phase 1 First‐in‐Human Single‐Ascending‐Dose Trial With ESB1609, a Selective Agonist to the Sphingosine‐1‐Phosphate Receptor 5

QPS

A Phase 1 First‐in‐Human Single‐Ascending‐Dose Trial With ESB1609, a Selective Agonist to the Sphingosine‐1‐Phosphate Receptor 5 Read More »

Safety, Tolerability, Pharmacokinetics and Initial Pharmacodynamics of a Subcommissural Organ-Spondin-Derived Peptide: A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose First-in-Human Study

QPS

Safety, Tolerability, Pharmacokinetics and Initial Pharmacodynamics of a Subcommissural Organ-Spondin-Derived Peptide: A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose First-in-Human Study Read More »

Comparison of the Pharmacokinetic Profiles of Trientine Tetrahydrochloride and Trientine Dihydrochloride in Healthy Subjects

QPS

Comparison of the Pharmacokinetic Profiles of Trientine Tetrahydrochloride and Trientine Dihydrochloride in Healthy Subjects Read More »

Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen‐Induced Platelet Aggregation

QPS

Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen‐Induced Platelet Aggregation Read More »

Effect of Rifampin‐Mediated OATP1B1 and OATP1B3 Transporter Inhibition on the Pharmacokinetics of the P2Y12 Receptor Antagonist Selatogrel

QPS

Effect of Rifampin‐Mediated OATP1B1 and OATP1B3 Transporter Inhibition on the Pharmacokinetics of the P2Y12 Receptor Antagonist Selatogrel Read More »

Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab: First-in-Human Healthy Volunteer Trial

QPS

Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab: First-in-Human Healthy Volunteer Trial Read More »

Influence of Rifampin-Mediated Organic Anion-Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan

QPS

Influence of Rifampin-Mediated Organic Anion-Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan Read More »

Two placebo-controlled crossover studies in healthy subjects to evaluate gastric acid neutralization by an alginate-antacid formulation (Gaviscon Double Action).

QPS

Two placebo-controlled crossover studies in healthy subjects to evaluate gastric acid neutralization by an alginate-antacid formulation (Gaviscon Double Action). Read More »

The absolute bioavailability and the effect of food on a new magnesium lactate dehydrate extended-release caplet in healthy subjects

QPS

The absolute bioavailability and the effect of food on a new magnesium lactate dehydrate extended-release caplet in healthy subjects Read More »

Asenapine pharmacokinetics and tolerability in a pediatric population

QPS

Asenapine pharmacokinetics and tolerability in a pediatric population Read More »

Safety and clinical effect of i.v. infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects

QPS

Safety and clinical effect of i.v. infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects Read More »

A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics-Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbony lmetomidate (ABP-700) after a Single Ascending Bolus Dose

QPS

A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics-Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbony lmetomidate (ABP-700) after a Single Ascending Bolus Dose Read More »

ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests

QPS

ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests Read More »

Generic medications in precision medicine in asthma

QPS

Generic medications in precision medicine in asthma Read More »

Role of biologics targeting type 2 airway inflammation in asthma: what have we learned so far?

QPS

Role of biologics targeting type 2 airway inflammation in asthma: what have we learned so far? Read More »

A new fully human recombinant FSH (follitropin epsilon): two phase I randomized placebo and comparator-controlled pharmacokinetic and pharmacodynamic trials

QPS

A new fully human recombinant FSH (follitropin epsilon): two phase I randomized placebo and comparator-controlled pharmacokinetic and pharmacodynamic trials Read More »

Toll-like Receptor 3 blockade in Rhinovirus-induced experimental asthma exacerbations: a randomized controlled study

QPS

Toll-like Receptor 3 blockade in Rhinovirus-induced experimental asthma exacerbations: a randomized controlled study Read More »

Phase I Study evaluating the safety, tolerability and pharmacokinetics of a novel oral dissolvable film containing dexamethasone versus fortecortin dexamethasone tablets

QPS

Phase I Study evaluating the safety, tolerability and pharmacokinetics of a novel oral dissolvable film containing dexamethasone versus fortecortin dexamethasone tablets Read More »

Phase I Study evaluating the safety, tolerability and pharmacokinetics of a novel oral dissolvable film containing dexamethasone versus fortecortin dexamethasone tablets

QPS

Phase I Study evaluating the safety, tolerability and pharmacokinetics of a novel oral dissolvable film containing dexamethasone versus fortecortin dexamethasone tablets Read More »