Part II: Advancing mRNA Therapeutics: Mastering LNP Quantification, Payload Analysis and Biodistribution Studies
In this interview, Lan Li, Susan Zondlo, Zamas Lam and Aurora VanAuken discuss the structure, function and analytical challenges of lipid nanoparticles (LNPs) used…
Part I: Choosing the Right Delivery Vehicle: Navigating the trade-offs between LNPs and Viral Vectors
In this expert opinion, Zamas Lam reviews the advantages and disadvantages of lipid nanoparticles (LNPs) and viral vectors for gene-based therapeutic delivery, including their…
Optimizing LC-MS Workflows to Support Drug Discovery
As drug candidates become increasingly diverse, bioanalytical laboratories must adapt workflows to accommodate molecules with a wide range of physicochemical properties while maintaining the…
Ask The Experts: Hybrid LBA/LC–MS
Historically, LBA and LC–MS have been acclaimed as gold-standard technologies in large molecule and small molecule quantification respectively. However, advances in the field have…
Ask The Experts: The Impact Of COVID-19 On The Lab
In this Ask the Experts feature, our experts explain how their laboratories have been affected by the COVID-19 pandemic, explore whether their institution will…
QPS Taiwan: New Facility Expansion And The Challenges Of Pharmacology Drug-Related Projects
In this interview, Charlene Chen (QPS; Taipei, Taiwan) summarizes what QPS hopes to achieve with their new Center of Toxicology and Preclinical Sciences, which…
Recent Developments In Oligonucleotide Analysis
In this Bioanalysis Zone interview, Zamas Lam (QPS; DE, USA) discusses various methods that can be used to quantify oligonucleotide drugs. Zamas also explains…
How Are Pharmacology Disease State Models Used For Drug Development?
In this interview with Meiling Hou (QPS; Taipei, Taiwan), we explore pharmacology studies and their role in drug development. Meiling explores the challenges of…
Innovative New Leukopak Facility At QPS
In this interview with Polung Yang (QPS; Taipei, Taiwan), we explore the evolution and innovation of automated procedures in primary cell procurement and delivery….
Electrophoretic Mobility Shift Assay (EMSA) As An Alternative Approach For The Estimation Of Plasma Protein Binding Of Oligonucleotides
In this interview, Wenbin Liu (QPS; DE, USA) walks us through the role of plasma protein binding (PPB) studies in drug development, focusing on…