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Peripheral Blood Mononuclear Cells (PBMCs)

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PBMC Services CRO for Reliable Sample Processing and Immune Analysis

Peripheral blood mononuclear cells (PBMCs) are immune cells, including T cells, B cells, NK cells, and mono-cytes, commonly used in immunology research, vaccine development, and clinical trials. PBMC isolation and analysis are critical for understanding immune response and therapeutic efficacy. QPS provides end-to-end PBMC services, including processing, isolation, cryopreservation, and bioanalysis to support clinical trials and immunology research worldwide.

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End-to-End PBMC Processing Services for Clinical and Research Programs

As a global PBMC services CRO, QPS delivers standardized peripheral blood mononuclear cell (PBMC) processing solutions to ensure sample integrity, reproducibility, and high-quality downstream data. Our PBMC processing services support both early-stage research and large-scale clinical trials.

Capabilities:

  • PBMC isolation using validated density gradient methods
  • PBMC sample processing for clinical trials
  • Cell counting and viability assessment
  • PBMC cryopreservation and storage
  • Global sample logistics and cold chain management
  • PBMC bioanalysis and immunological assays
  • Integration with Phase I–IV clinical studies
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A Trusted CRO for PBMC Processing and Clinical Trial Support

QPS combines scientific expertise with global infrastructure to deliver reliable PBMC CRO services for im- munology, vaccine, and cell therapy programs.

Key Advantages:

  • PBMC Clinical Trial Support
    Coordinated PBMC sample collection and processing across North America (shipping), and same day with- in a 4 hour drive of our Clinical Trial Units in Springfield, MO and Miami, FL.
Map 4 hour drive from Springfield MO
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We often work outside of normal working hours to isolate and preserve these samples. We also can offer
personalized preparation manuals to allow for 24-hour stability of the samples for shipping.

  • Standardized PBMC Processing
    Consistent protocols ensure reproducible PBMC isolation and high cell viability across sites.
  • Regulatory-Ready PBMC Data
    Compliant workflows aligned with FDA and international regulatory expectations.
  • Scalable PBMC Services
    Flexible support for small research studies and large, multi-site clinical trials.

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PBMC Services for Immunology, Vaccine, and Cell Therapy Research

Our PBMC CRO services support a wide range of therapeutic and research applications.

Use Cases:

  • PBMC services for vaccine development
  • PBMC analysis in immuno-oncology
  • PBMC support for cell and gene therapy
  • PBMC testing for infectious disease studies
  • PBMC-based biomarker research

QPS PBMC processing workflow: PBMC Isolation, Cryopreservation, and Bioanalysis Workflow

Steps:

1

Sample Collection

PBMC blood samples collected at clinical sites

2

PBMC Isolation

Standardized density gradient separation

3

Cryopreservation & Storage

Controlled-rate freezing for long term PBMC storage

4

PBMC Bioanalysis

Immune profiling, biomarker analysis, and functional assays

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Using a Density Gradient Reagent to separate PBMCs from plasma and RBCs

Proven PBMC Processing Performance

  • Thousands of PBMC samples processed across global clinical studies
  • High PBMC viability and recovery rates post-thaw
  • Experience supporting PBMC clinical trial services (Phase I–II)
  • Integrated PBMC bioanalytical and clinical capabilities

PBMC Frequently Asked Questions

Peripheral Blood Mononuclear Cells (PBMCs) are immune cells found in the bloodstream that have a single round nucleus. These cells include T cells, B cells, natural killer (NK) cells, and monocytes. PBMCs play a critical role in the body’s immune response and are widely used in immunology, vaccine development, infectious disease research, oncology, and transplant studies.

PBMC samples typically contain several types of immune cells, including:

  • T Cells: 60–70%
  • Monocytes/Macrophages: 15%
  • Natural Killer (NK) Cells: 15%
  • B Cells: 10%

These cells work together to support both innate and adaptive immune responses.
QPS isolates PBMCs using density gradient centrifugation, which separates PBMCs from plasma, red blood cells, and other blood components. After isolation, the cells are washed, counted, evaluated for quality, and cryopreserved for storage or shipment. QPS also offers whole blood stimulation procedures and supports PBMC processing as either a standalone service or as part of a full-service clinical trial.

PBMCs are commonly used to study immune responses in clinical trials for vaccines and new therapeutics. Researchers use PBMCs in applications such as:

  • Flow cytometry
  • ELISpot assays
  • Cytokine analysis
  • Immune response monitoring
  • Vaccine evaluation
  • Infectious disease and cancer research

Because PBMCs reflect cellular immune activity, they are valuable tools for assessing how the immune system responds to treatments and vaccines.

QPS operates two fully equipped PBMC laboratories staffed by experienced technicians. These facilities allow QPS to support long-term PBMC storage, cryopreservation, processing, and clinical trial sample management.

Our facilities include:

  • Class II biosafety cabinet hoods
  • Liquid nitrogen storage tanks capable of storing over 10,000 PBMC samples
  • Dual fluorescence automatic cell counters
  • -80°C freezers
  • Centrifuges

Links to Relevant Documents

Leadership

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Partner with Us

Partner with QPS for high-quality PBMC processing, scalable clinical support, and regulatory-ready data.

Visit: https://www.qps.com/

Set Up a Meeting: https://www.qps.com/contact
Email: info@qps.com

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