ICMP-MS (Mass Spectrometry)
QPS is a leader in elemental analysis for pharmaceutical research.
For a small but important number of compounds, inductively coupled plasma mass spectrometry (ICP-MS) is a good alternative quantitative and qualitative method. In ICP-MS (Mass Spectrometry), the samples are ionized by an inductively coupled plasma followed by separation and detection on an elemental mass spectrometer. Due to its high sensitivity and less cumbersome pretreatment procedures when compared to other mass spectrometry techniques, inductively coupled plasma mass spectrometry is a valuable tool in elemental analysis.
SOME OF THE FEATURES OF THIS USEFUL TOOL:
- ICP-MS detects elements instead of molecules: With the exception of a few elements (C, H, N, O and the noble gasses), all elements can be detected. A specific element serves as a tag for the drug molecule of interest, thus enabling quantitation of this drug molecule in a particular matrix. The technique is highly linear and can be used quantitatively for a broad concentration range. Sample processing is relatively straightforward with high throughput resulting in fast turnaround times.
- ICP-MS measures total concentration. Typical applications of ICP-MS are pharmacokinetic, imaging, mass balance, pharmacodynamics, and toxicology studies. Furthermore ICP-MS is frequently used for limit tests of elements, trace elemental analysis, and formulation analysis.
- ICP-MS measures molecule-specific concentration. LC-ICP-MS measures the element concentration of all compounds present in the matrix that contain the element of interest and which are chromatographically separated. LC-ICP-MS enables metabolite profiling and determination of biotransformation and/or degradation products.
- ICP-MS is capable of multi-element analysis.
- ICP-MS can be combined with LC-MS/MS (parallel detection).
- ICP-MS can be used as detector for ELISA assays.