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SCIENTIFIC REFERENCE

Neuropharmacology

The following articles are hyperlinked to the abstract of the article:

2023

Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models

Shirin Sharghi, Stefanie Flunkert, Magdalena Daurer, Roland Rabl, Boris Philippe Chagnaud, Marcello Leopoldo, Enza Lacivita, Birgit Hutter-Paier and Manuela Prokesch.

Front. Neurosci. 17:1087788. 30. March 2023 doi: 0.3389/fnins.2023.1087788
Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease

Vijay R Varma, Rishi J Desai, Sheeja Navakkode, Lik-Wei Wong, Carlos Anerillas, Tina Loeffler, Irene Schilcher, Mufaddal Mahesri, Kristyn Chin, Daniel B Horton, Seoyoung C Kim, Tobias Gerhard, Jodi B Segal, Sebastian Schneeweiss, Myriam Gorospe, Sreedharan Sajikumar, Madhav Thambisetty

Mol Psychiatry. 2022 Dec 28. doi: 10.1038/s41380-022-01912-0.

2022

Leukotriene Signaling as a Target in α-Synucleinopathies

Katharina Strempfl, Michael S. Unger, Stefanie Flunkert, Andrea Trost, Herbert A. Reitsamer, Birgit Hutter-Paier and Ludwig Aigner

Biomolecules. 2022 Feb 23;12(3):346. doi: 10.3390/biom12030346.

2021

Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation

Kristina Dominko, Ana Rastija, Sandra Sobocanec, Lea Vidatic, Sarah Meglaj, Andrea Lovincic Babic, Birgit Hutter-Paier, Alessio-Vittorio Colombo, Stefan F Lichtenthaler, Sabina Tahirovic, Silva Hecimovic

Int J Mol Sci. 2021 Dec 9;22(24):13256.doi: 10.3390/ijms222413256
Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice

Torsten Hoffmann, Jens-Ulrich Rahfeld, Mathias Schenk, Falk Ponath, Koki Makioka, Birgit Hutter-Paier, Inge Lues, Cynthia A Lemere, Stephan Schilling

Int J Mol Sci. 2021 Oct 30;22(21):11791. DOI: 10.3390/ijms222111791
A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets

Jackson A Roberts, Vijay R Varma, Yang An, Sudhir Varma, Julián Candia, Giovanna Fantoni, Vinod Tiwari, Carlos Anerillas, Andrew Williamson, Atsushi Saito, Tina Loeffler, Irene Schilcher, Ruin Moaddel, Mohammed Khadeer, Jacqueline Lovett, Toshiko Tanaka, Olga Pletnikova, Juan C Troncoso, David A Bennett, Marilyn S Albert, Kaiwen Yu, Mingming Niu, Vahram Haroutunian, Bin Zhang, Junmin Peng, Deborah L Croteau, Susan M Resnick, Myriam Gorospe, Vilhelm A Bohr, Luigi Ferrucci, Madhav Thambisetty

Sci Adv. 2021 Nov 12;7(46):eabi8178. DOI: 10.1126/sciadv.abi8178
CD4 + T cells contribute to neurodegeneration in Lewy body dementia

David Gate, Emma Tapp, Olivia Leventhal, Marian Shahid, Tim J Nonninger, Andrew C Yang, Katharina Strempfl, Michael S Unger, Tobias Fehlmann, Hamilton Oh, Divya Channappa, Victor W Henderson, Andreas Keller, Ludwig Aigner, Douglas R Galasko, Mark M Davis, Kathleen L Poston, Tony Wyss-Coray

Science. 2021 Oct 14;eabf7266. doi: 10.1126/science.abf7266
Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling

Thomas Filip, Severin Mairinger, Joerg Neddens, Michael Sauberer, Stefanie Flunkert, Johann Stanek, Thomas Wanek, Nobuyuki Okamura, Oliver Langer, Birgit Hutter-Paier, Claudia Kuntner

Alzheimers Res Ther. 2021 Oct 16;13(1):175. doi: 10.1186/s13195-021-00916-2
Evaluation of Neuropathological Features in the SOD1-G93A Low Copy Number Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Agnes Molnar-Kasza†, Barbara Hinteregger†, Joerg Neddens, Roland Rabl, Stefanie Flunkert and Birgit Hutter-Paier

Front. Mol. Neurosci., 24 June 2021 | https://doi.org/10.3389/fnmol.2021.681868
Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer’s Disease

Barbara Hinteregger, Tina Loeffler, Stefanie Flunkert, Joerg Neddens, Thomas A Bayer, Tobias Madl, Birgit Hutter-Paier

J Alzheimers Dis. 2021 Feb 25.
doi: 10.3233/JAD-201204
The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice

Johanna Michael, Julia Zirknitzer, Michael Stefan Unger, Rodolphe Poupardin, Tanja Rieß, Nadine Paiement, Horst Zerbe, Birgit Hutter-Paier, Herbert Reitsamer, Ludwig Aigner

Int J Mol Sci. 2021 Mar 9;22(5):2782.
doi: 10.3390/ijms22052782
Homozygosity of BACHD rats not only causes strong behavioral deficits in young female rats but also a reduced breeding success

Stephan Kurat, Petra Heinrich, Agnes Molnar-Kasza, Tina Loeffler, Stefanie Flunkert, Birgit Hutter-Paier

Brain Res. 2021 Mar 2;1761:147396.
doi: 10.1016/j.brainres.2021.147396.
Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein

Wim Hendricus Quint, Irena Matečko-Burmann, Irene Schilcher, Tina Löffler, Michael Schöll, Björn Marcus Burmann, Thomas Vogels

J Alzheimers Dis. 2021 Feb 12.
doi: 10.3233/JAD-201334
Quantification of Huntington’s Disease Related Markers in the R6/2 Mouse Model

Estibaliz Etxeberria-Rekalde, Saioa Alzola-Aldamizetxebarria, Stefanie Flunkert, Isabella Hable, Magdalena Daurer, Joerg Neddens and Birgit Hutter-Paier

Front. Mol. Neurosci., 11 January 2021
doi.org/10.3389/fnmol.2020.617229

2020

Improved Bioavailability of Montelukast through a Novel Oral Mucoadhesive Film in Humans and Mice

Johanna Michael, Diana Bessa de Sousa, Justin Conway, Erick Gonzalez-Labrada, Rodolphe Obeid, Julia Tevini, Thomas Felder, Birgit Hutter-Paier, Horst Zerbe, Nadine Paiement, Ludwig Aigner

Pharmaceutics. 2020 Dec 23;13(1):E12. doi: 10.3390/pharmaceutics13010012.
Constant Levels of Tau Phosphorylation in the Brain of htau Mice

Joerg Neddens, Magdalena Daurer, Tina Loeffler, Saioa Alzola Aldamizetxebarria, Stefanie Flunkert, Birgit Hutter-Paier

Front Mol Neurosci 2020 Aug 28;13:136. doi: 10.3389/fnmol.2020.00136. eCollection 2020. 
Correlation of Pyroglutamate Amyloid β and Ptau Ser202/Thr205 Levels in Alzheimer’s Disease and Related Murine Models

Joerg Neddens, Magdalena Daurer, Stefanie Flunkert, Kerstin Beutl, Tina Loeffler, Lauren Walker, Johannes Attems, Birgit Hutter-Paier

PLoS One. 2020 Jul 9;15(7):e0235543. doi: 10.1371/journal.pone.0235543. eCollection 2020.
Validation of Behavioral Phenotypes in the BACHD Rat Model

Arianna Novati, Giuseppe Manfré, Stefanie Flunkert, Johanneke E Van der Harst, Judith R Homberg, Robert Wronski, Huu Phuc Nguyen

Behav Brain Res. 2020 Jun 20;112783. doi: 10.1016/j.bbr.2020.112783.
Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value

Tina Loeffler, Irene Schilcher, Stefanie Flunkert, and Birgit Hutter-Paier

Front. Neurosci., 11 June 2020
CD8 + T-cells Infiltrate Alzheimer’s Disease Brains and Regulate Neuronal- And Synapse-Related Gene Expression in APP-PS1 Transgenic Mice

M S Unger, E Li, L Scharnagl, R Poupardin, B Altendorfer, H Mrowetz, B Hutter-Paier, T M Weiger, M T Heneka, J Attems, L Aigner

Brain Behav Immun 2020 May 29;S0889-1591(19)31573-9. doi: 10.1016/j.bbi.2020.05.070.
Transgene integration causes RARB downregulation in homozygous Tg4-42 mice.

Hinteregger B, Loeffler T, Flunkert S, Neddens J, Birner-Gruenberger R, Bayer TA, Madl T, Hutter-Paier B.

Sci Rep. 2020 Apr 14;10(1):6377. doi: 10.1038/s41598-020-63512-8.
The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies.

Marschallinger J, Altendorfer B, Rockenstein E, Holztrattner M, Garnweidner-Raith J, Pillichshammer N, Leister I, Hutter-Paier B, Strempfl K, Unger MS, Chishty M, Felder T, Johnson M, Attems J, Masliah E, Aigner L.

Neurotherapeutics (February 2020)
Plasma pharmacokinetic and metabolism of [18F]THK-5317 are dependent on sex.

Mairinger S, Filip T, Sauberer M, Flunkert S, Wanek T, Stanek J, Furtner S, Hutter-Paier B, Okamura N, Kuntner C.

Nucl Med Biol. (January 2020)
Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice.

Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O’Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA

Alzheimers Res Ther. (January 2020)
Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease.

Schiffer V, Santiago-Mujika E, Flunkert S, Schmidt S, Farcher M, Loeffler T, Schilcher I, Posch M, Neddens J, Sun Y, Kehr J, Hutter-Paier B

PLOS ONE (January 2020)

 

2019

Correction: Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease.

Clemensson EKH, Clemensson LE, Fabry B, Flunkert S, Riess O, Wronski R, Nguyen HP.

PLOS ONE (March 2019)
Hepatic and neuronal phenotype of NPC1−/− mice

Estibaliz Santiago-Mujica1, Stefanie Flunkert1, Roland Rabl, Joerg Neddens, Tina Loeffler, Birgit Hutter-Paier

(February 2019)

2018

Development of GMP-1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer’s disease.

Pavlov PF, Hutter-Paier B, Havas D, Windisch M, Winblad B.

Journal of Cellular and Molecular Medicine (July 2018)
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.

Causevic M, Dominko K, Malnar M, Vidatic L, Cermak S, Pigoni M, Kuhn PH, Colombo A, Havas D, Flunkert S, McDonald J, Gunnersen JM, Hutter-Paier B, Tahirovic S, Windisch M, Krainc D, Lichtenthaler SF, Hecimovic S.

PLOS ONE (July 2018)
Phosphorylation of different tau sites during progression of Alzheimer’s disease.

Neddens J, Temmel M, Flunkert S, Kerschbaumer B, Hoeller C, Loeffler T, Niederkofler V, Daum G, Attems J, Hutter-Paier B.

Acta Neuropathologica Communications (June 2018)
mTh1 driven expression of hTDP-43 results in typical ALS/FTLD neuropathological symptoms.

Scherz B, Rabl R, Flunkert S, Rohler S, Neddens J, Taub N, Temmel M, Panzenboeck U, Niederkofler V, Zimmermann R, Hutter-Paier B.

PLOS ONE (May 2018)

2017

Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer’s Disease.

Kutzsche J, Schemmert S, Tusche M, Neddens J, Rabl R, Jürgens D, Brener O, Willuweit A, Hutter-Paier B, Willbold D.

Molecules (October 2017)
SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer’s disease.

Brunner D, Flunkert S, Neddens J, Duller S, Scopes DIC, Treherne JM, Hutter-Paier B.

Neuroscience Letters (September 2017)
Nortriptyline inhibits aggregation and neurotoxicity of alpha-synuclein by enhancing reconfiguration of the monomeric form.

Collier TJ, Srivastava KR, Justman C, Grammatopoulous T, Hutter-Paier B, Prokesch M, Havas D, Rochet JC, Liu F, Jock K, de Oliveira P, Stirtz GL, Dettmer U, Sortwell CE, Feany MB, Lansbury P, Lapidus L, Paumier KL.

Neurobiolgy of Disease (July, 2017)
Glutaminyl Cyclase Inhibitor PQ912 improves cognition in mouse models of Alzheimer’s disease – studies on relation to effective target occupancy.

Hoffmann T, Meyer A, Heiser U, Kurat S, Bohme L, Kleinschmidt M, Buhring KU, Hutter-Paier B, Farcher M, Demuth HU, Lues I, Schilling S.

The Journal of Pharmacology and Experimental Therapeutics (April, 2017)
Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice.

Rabl R, Breitschaedel C, Flunkert S, Duller S, Amschl D, Neddens J, Niederkofler V, Rockenstein E, Masliah E, Roemer H, Hutter-Paier B.

BMC Neuroscience (January 2017)

2016

Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging.

Khairnar A, Ruda-Kucerova J, Szabó N, Drazanova E, Arab A, Hutter-Paier B, Neddens J, Latta P, Starcuk Z Jr, Rektorova I.

Brain, Behavior, and Immunity (December, 2016)
Quantitative evaluation of orofacial motor function in mice: The pasta gnawing test, a voluntary and stress-free behavior test.

Rabl R, Horvath A, Breitschaedel C, Flunkert S, Roemer H, Hutter-Paier B.

Journal of Neuroscience Methods (October 2016)
Decreased Plasma Aβ in Hyperlipidemic APPSL Transgenic Mice is Associated with BBB Dysfunction.

Löffler T, Flunkert S, Temmel M, Hutter-Paier B.

Frontiers in Neuroscience (June, 2016)
Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice.

Löffler T, Schweinzer C, Flunkert S, Sántha M, Windisch M, Steyrer E, Hutter-Paier B.

Molecular and Cellular Neuroscience (March, 2016)

2015

Late-stage α-synuclein accumulation in TNWT-61 mouse model of Parkinson’s disease detected by diffusion kurtosis imaging.

Khairnar A, Ruda-Kucerova J, Drazanova E, Szabó N, Latta P, Arab A, Hutter-Paier B, Havas D, Windisch M, Sulcova A, Starcuk Z Jr, Király A, Rektorova I.

Journal of Neurochemistry (December, 2015)
Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of α-Synuclein Overexpressing Transgenic Mouse Model of Parkinson’s Disease: A Pilot Study.

Khairnar A, Latta P, Drazanova E, Ruda-Kucerova J, Szabó N, Arab A, Hutter-Paier B, Havas D, Windisch M, Sulcova A, Starcuk Z Jr, Rektorova I.

Neurotox Res. 2015 Jul 8.
Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound

Sola I, Viayna E, Gómez T, Galdeano C, Cassina M, Camps P, Romeo M, Diomede L, Salmona M, Franco P, Schaeffer M, Colantuono D, Robin D, Brunner D, Taub N, Hutter-Paier B, Muñoz-Torrero D.

Molecules (2015)
Long-term treatment of aged Long Evans rats with a dietary supplement containing neuroprotective peptides (N-PEP-12) to prevent brain aging: effects of three months daily treatment by oral gavage

Hutter-Paier B, Reininger-Gutmann B, Wronski R, Doppler E, Moessler H.

Journal Of Medicine and Life (2015)
Influence of Lentiviral β-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer’s Disease on Amyloid Precursor Protein Metabolism and Pathology

Krassnig S, Schweinzer C, Taub N, Havas D, Auer E, Flunkert S, Schreibmayer W, Hutter-Paier B, Windisch M.

Neurodegenerative Diseases (2015)

2014

L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model

Daschil N, Kniewallner KM, Obermair GJ, Hutter-Paier B, Windisch M, Marksteiner J, Humpel C.

Neurobiol Aging. (December, 2014)
Alzheimer’s Therapeutics Targeting Amyloid Beta 1 – 42 Oligomers I: Abeta42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

Izzo NJ, Staniszewski A, To L, Fa M, Teich AF, Saeed F, Wostein H, Walko T 3rd, Vaswani A, Wardius M, Syed Z, Ravenscroft J, Mozzoni K, Silky C, Rehak C, Yurko R, Finn P, Look G, Rishton G, Safferstein H, Miller M, Johanson C, Stopa E, Windisch M, Hutter-Paier B, Shamloo M, Arancio O, LeVine H 3rd, Catalano SM.

PLOS ONE (November, 2014)
Tracking of Magnetite Labeled Nanoparticles in the Rat Brain Using MRI

Naira P. Martínez Vera, Reinhold Schmidt, Klaus Langer, Iavor Zlatev, RobertWronski, Ewald Auer, Daniel Havas, Manfred Windisch, Hagen von Briesen, Sylvia Wagner, Julia Stab, Motti Deutsch, Claus Pietrzik, Franz Fazekas, Stefan Ropele

PLOS ONE (March, 2014)
Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivo model of Alzheimer’s disease

Tina Löffler, Stefanie Flunkert, Daniel Havas, Cornelia Schweinzer, Marni Uger, Manfred Windisch, Ernst Steyrer, Birgit Hutter-Paier

Journal of Neuroinflammation (2014)

2013

Time course and progression of wild type a-Synuclein accumulation in a transgenic mouse model.

Amschl D, Neddens J, Havas D, Flunkert S, Rabl R, Römer H, Rockenstein E, Masliah E, Windisch M, Hutter-Paier B.

BMC Neuroscience. 2013
Commentary to the recently published review “Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer’s disease” by Li, Evrahimi and Schluesener. Ageing Res. Rev. 2013 Jan;12(1):116-40.

Windisch M, Flunkert S, Havas D, Hutter-Paier B.

Ageing Research Reviews (2013)
In Vivo and Ex Vivo Imaging of Amyloid-ß Cascade Aggregates with a Pronucleon™ Peptide.

Nyborg AC, Moll JR, Wegrzyn RD, Havas D, Hutter-Paier B, Rudolph AS, Feuerstein G.

Journal of Alzheimer’s Disease (2013)
CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-β plaques in an Alzheimer’s disease mouse model.

Paganetti P, Antoniello K, Devraj K, Toni N, Kieran D, Madani R, Pihlgren M, Adolfsson O, Froestl W, Schrattenholz A, Liebner S, Havas D, Windisch M, Cirrito JR, Pfeifer A, Muhs A.

Journal of Alzheimer’s Disease (2013)
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon.

Rosini M, Simoni E, Bartolini M, Soriano E, Marco-Contelles J, Andrisano V, Monti B, Windisch M, Hutter-Paier B, McClymont DW, Mellor IR, Bolognesi ML.

ChemMedChem (2013)
Increased Efflux of Amyloid-β Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis.

Paganetti P, Antoniello K, Devraj K, Toni N, Kieran D, Madani R, Pihlgren M, Adolfsson O, Froestl W, Schrattenholz A, Liebner S, Havas D, Windisch M, Cirrito JR, Pfeifer A, Muhs A.

Journal of Alzheimer’s Disease (2013)
Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice.

Löffler T, Flunkert S, Havas D, Sántha M, Hutter-Paier B, Steyrer E, Windisch M.

Neurobiol Aging (2013)

2012

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.

Nussbaum JM, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Rönicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, Glabe CG, Demuth HU, Bloom GS.

Nature (2012)
Elevated Levels of Soluble Total and Hyperphosphorylated Tau Result in Early Behavioral Deficits and Distinct Changes in Brain Pathology in a New Tau Transgenic Mouse Model.

Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, Schofield EL, Ward MA, Posch M, Jungwirth H, Windisch M, Hutter-Paier B.

Neurodegenerative Diseases (2012)
Modulation of gamma-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice.

Rogers K, Felsenstein KM, Hrdlicka L, Tu Z, Albayya F, Lee W, Hopp S, Miller MJ, Spaulding D, Yang Z, Hodgdon H, Nolan S, Wen M, Costa D, Blain JF, Freeman E, De Strooper B, Vulsteke V, Scrocchi L, Zetterberg H, Portelius E, Hutter-Paier B,Havas D, Ahlijanian M, Flood D, Leventhal L, Shapiro G, Patzke H, Chesworth R, Koenig G.

Molelcular Neurodegeneration (2012)

2011

A Longitudinal Study of Behavioral Deficits in an AβPP Transgenic Mouse Model of Alzheimer’s Disease.

Havas D, Hutter-Paier B, Ubhi K, Rockenstein E, Crailsheim K, Masliah E, Windisch M.

Journal of Alzheimer’s Disease (2011)
Synthesis of monomeric derivatives to probe memoquin’s bivalent interactions.

Bolognesi ML, Chiriano G, Bartolini M, Mancini F, Bottegoni G, Maestri V, Czvitkovich S, Windisch M, Cavalli A, Minarini A, Rosini M, Tumiatti V, Andrisano V, Melchiorre C.

Journal of Medicinal Chemistry (2011)
Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease.

Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C.

Alzheimer’s Research & Therapy (2011)
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