DMPK

LC-TOF-MS methods to quantify siRNAs and major metabolites in plasma, urine and tissues.

QPS

LC-TOF-MS methods to quantify siRNAs and major metabolites in plasma, urine and tissues. Read More »

Metabolism, Excretion, and Pharmacokinetics of [14C]-Cefiderocol (S-649266), a Siderophore Cephalosporin, in Healthy Subjects Following Intravenous Administration

QPS

Metabolism, Excretion, and Pharmacokinetics of [14C]-Cefiderocol (S-649266), a Siderophore Cephalosporin, in Healthy Subjects Following Intravenous Administration Read More »

Pharmacokinetics, distribution, metabolism, and excretion of the dual reuptake inhibitor [14C]-nefopam in rats

QPS

Pharmacokinetics, distribution, metabolism, and excretion of the dual reuptake inhibitor [14C]-nefopam in rats Read More »

Autoradiography Techniques and Quantification of Drug Distribution

QPS

Autoradiography Techniques and Quantification of Drug Distribution Read More »

Metabolism and Disposition of Cabozantinib in Healthy Male Volunteers and Pharmacologic Characterization of Its Major Metabolites.

QPS

Metabolism and Disposition of Cabozantinib in Healthy Male Volunteers and Pharmacologic Characterization of Its Major Metabolites. Read More »

Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening

QPS

Absorption, Distribution, Metabolism, and Excretion of [14C]GDC-0449 (Vismodegib), an Orally Active Hedgehog Pathway Inhibitor, in Rats and Dogs: A Unique Metabolic Pathway via Pyridine Ring Opening Read More »

Autoradiography, MALDI-MS, and SIMS-MS Imaging in Pharmaceutical Discovery and Development

QPS

Autoradiography, MALDI-MS, and SIMS-MS Imaging in Pharmaceutical Discovery and Development Read More »

Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies

QPS

Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies Read More »

Autoradiography, MALDI-MS, and SIMS-MS Imaging in Pharmaceutical Discovery and Development

QPS

Autoradiography, MALDI-MS, and SIMS-MS Imaging in Pharmaceutical Discovery and Development Read More »

Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies

QPS

Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies Read More »

Criteria for selecting pharmacokinetic repeat study samples

QPS

Criteria for selecting pharmacokinetic repeat study samples Read More »

The Distribution Pattern of Intravenous [14C] Artesunate in Rat Tissues by Quantitative Whole-body Autoradiography and Tissue Dissection Techniques

QPS

The Distribution Pattern of Intravenous [14C] Artesunate in Rat Tissues by Quantitative Whole-body Autoradiography and Tissue Dissection Techniques Read More »

Role of Intestinal P-Glycoprotein in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents

QPS

Role of Intestinal P-Glycoprotein in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents Read More »

Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor a-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A transporter-Based Drug-Drug Interaction Case Study

QPS

Effect of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a Human Tumor Necrosis Factor a-Converting Enzyme Inhibitor, on the Disposition of Methotrexate: A transporter-Based Drug-Drug Interaction Case Study Read More »

Prodrugs to Reduce Presystemic Metabolism

QPS

Prodrugs to Reduce Presystemic Metabolism Read More »

Effects of tibolone on sulfatase pathway of estrogens metabolism and on growth of MCF-7 human breast tumors implanted in ovariectomized nude mice

QPS

Effects of tibolone on sulfatase pathway of estrogens metabolism and on growth of MCF-7 human breast tumors implanted in ovariectomized nude mice Read More »

Distribution of Radioactivity in Bone and Related Structures following Administration of [14C]Dalbavancin to New Zealand White Rabbits

QPS

Distribution of Radioactivity in Bone and Related Structures following Administration of [14C]Dalbavancin to New Zealand White Rabbits Read More »

Autoradiography: High-Resolution Molecular Imaging in Pharmaceutical Discovery and Development

QPS

Autoradiography: High-Resolution Molecular Imaging in Pharmaceutical Discovery and Development Read More »

Limited Interaction between Tacrolimus and P-Glycoprotein in the Rat Small Intestine

QPS

Limited Interaction between Tacrolimus and P-Glycoprotein in the Rat Small Intestine Read More »

Increased Hepatobiliary Clearance of Unconjugated Thyroxine Determines DMP 904-Induced Alterations in Thyroid Hormone Homeostasis in Rats

QPS

Increased Hepatobiliary Clearance of Unconjugated Thyroxine Determines DMP 904-Induced Alterations in Thyroid Hormone Homeostasis in Rats Read More »