Decreased Plasma Aฮฒ in Hyperlipidemic APPSL Transgenic Mice is Associated with BBB Dysfunction. QPS Decreased Plasma Aฮฒ in Hyperlipidemic APPSL Transgenic Mice is Associated with BBB Dysfunction. Read More ยป
Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice. QPS Brain cortical cholesterol metabolism is highly affected by human APP overexpression in mice. Read More ยป
Late-stage ฮฑ-synuclein accumulation in TNWT-61 mouse model of Parkinson’s disease detected by diffusion kurtosis imaging. QPS Late-stage ฮฑ-synuclein accumulation in TNWT-61 mouse model of Parkinson’s disease detected by diffusion kurtosis imaging. Read More ยป
Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of ฮฑ-Synuclein Overexpressing Transgenic Mouse Model of Parkinson’s Disease: A Pilot Study. QPS Diffusion Kurtosis Imaging Detects Microstructural Alterations in Brain of ฮฑ-Synuclein Overexpressing Transgenic Mouse Model of Parkinson’s Disease: A Pilot Study. Read More ยป
Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound QPS Multigram Synthesis and in Vivo Efficacy Studies of a Novel Multitarget Anti-Alzheimer’s Compound Read More ยป
Long-term treatment of aged Long Evans rats with a dietary supplement containing neuroprotective peptides (N-PEP-12) to prevent brain aging: effects of three months daily treatment by oral gavage QPS Long-term treatment of aged Long Evans rats with a dietary supplement containing neuroprotective peptides (N-PEP-12) to prevent brain aging: effects of three months daily treatment by oral gavage Read More ยป
Influence of Lentiviral ฮฒ-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer’s Disease on Amyloid Precursor Protein Metabolism and Pathology QPS Influence of Lentiviral ฮฒ-Synuclein Overexpression in the Hippocampus of a Transgenic Mouse Model of Alzheimer’s Disease on Amyloid Precursor Protein Metabolism and Pathology Read More ยป
L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model QPS L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model Read More ยป
Alzheimerโs Therapeutics Targeting Amyloid Beta 1 – 42 Oligomers I: Abeta42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits QPS Alzheimerโs Therapeutics Targeting Amyloid Beta 1 – 42 Oligomers I: Abeta42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits Read More ยป
Tracking of Magnetite Labeled Nanoparticles in the Rat Brain Using MRI QPS Tracking of Magnetite Labeled Nanoparticles in the Rat Brain Using MRI Read More ยป
Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivo model of Alzheimerโs disease QPS Neuroinflammation and related neuropathologies in APPSL mice: further value of this in vivo model of Alzheimerโs disease Read More ยป
Time course and progression of wild type a-Synuclein accumulation in a transgenic mouse model. QPS Time course and progression of wild type a-Synuclein accumulation in a transgenic mouse model. Read More ยป
Commentary to the recently published review “Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer’s disease” by Li, Evrahimi and Schluesener. Ageing Res. Rev. 2013 Jan;12(1):116-40. QPS Commentary to the recently published review “Drug pipeline in neurodegeneration based on transgenic mice models of Alzheimer’s disease” by Li, Evrahimi and Schluesener. Ageing Res. Rev. 2013 Jan;12(1):116-40. Read More ยป
In Vivo and Ex Vivo Imaging of Amyloid-ร Cascade Aggregates with a Pronucleonโข Peptide. QPS In Vivo and Ex Vivo Imaging of Amyloid-ร Cascade Aggregates with a Pronucleonโข Peptide. Read More ยป
CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-ฮฒ plaques in an Alzheimer’s disease mouse model. QPS CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-ฮฒ plaques in an Alzheimer’s disease mouse model. Read More ยป
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon. QPS The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon. Read More ยป
Increased Efflux of Amyloid-ฮฒ Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis. QPS Increased Efflux of Amyloid-ฮฒ Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis. Read More ยป
Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice. QPS Impact of ApoB-100 expression on cognition and brain pathology in wild-type and hAPPsl mice. Read More ยป
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-ฮฒ. QPS Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-ฮฒ. Read More ยป
Elevated Levels of Soluble Total and Hyperphosphorylated Tau Result in Early Behavioral Deficits and Distinct Changes in Brain Pathology in a New Tau Transgenic Mouse Model. QPS Elevated Levels of Soluble Total and Hyperphosphorylated Tau Result in Early Behavioral Deficits and Distinct Changes in Brain Pathology in a New Tau Transgenic Mouse Model. Read More ยป
