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Technical Considerations of Pharmacokinetic Assays for LNP‑mRNA Drug Products by RT‑qPCR

Jason Pennucci, Amanda Hays, Wendy Adamowicz, Mitra Azadeh, Mohamed Benhammadi, Enric Bertran Portabella, MingLai Cheng, Kelly Colletti, Sanjay L. Dholakiya, Rajitha Doddareddy, Lara Duchstein, Jennifer Durham, Sebastian Guelman, Bryan Gullick, Kate Herr, Darshana Jani, Niketa Jani, Oskar Johansson, Kaarthik John, Mikael Kubista, Amy Lavelle, Geng Li, Yanchun Li, Hsing‑Yin Liu, Timothy Lochmann, Haiyan Ma, Benjamin Moritz, Jacqueline Murphy, Alice Park, Suresh Peddigari, Marie‑Soleil Piche, Swarna Suba Ramaswamy, Asha Reddy, Muriel Smet, Johannes Stanta, Jenny Valentine, Katherine Veirs, Venkata Vepachedu, Mark Wissel, Meizhen Wu, Bin Xu, Susan Zondlo

The AAPS Journal I September 18, 2025

Combined GPR40 and GPR119 full agonism with K-757 and K-833 results in robust glucose lowering and modest weight loss in overweight/obese subjects with T2DM

Michael Crutchlow, Jiajun Liu, Martha Hernandez-Illas, Harry Zhang, Anna Arreglado, Annemarie Vance, Daniel Boisvert, Giuseppe Terracina, Brett Lauring

Diabetes, Obesity and Metabolism – Wiley Online Library I August 06, 2025

Non-clinical and first-in-human characterization of ECC5004/AZD5004, a novel once-daily, oral small-molecule GLP-1 receptor agonist

Amina Z Haggag, Jianfeng Xu, Laurie Butcher, Sandra Pagnussat, Graeme Davies, Sara Lundqvist, Wenyu Wang, Natalie Van Zuydam, Karin Nelander, Aruni Jha, Hongtao Yu, Alessandro Boianelli, Bosse Lindmark, Anna Ollerstam, Xuefeng Sun, Fan Wang, Xiaoliang Pan, Haihui Liu, Wengang Chen, Jianfeng Xu, Kristina Wallenius, Jingye Zhou

Diabetes, Obesity and Metabolism – Wiley Online Library I February 27, 2025

Once-daily oral small-molecule glucagon-like peptide-1 receptor agonist lotiglipron (PF-07081532) for type 2 diabetes and obesity: Two randomized, placebo-controlled, multiple-ascending-dose Phase 1 studies

Clare Buckeridge, Nikolaos Tsamandoura, Santos Carvajal-Gonzalez, Lisa S Brown, Martha Hernandez-Illas, Aditi R Saxena

Diabetes, Obesity and Metabolism – Wiley Online Library I August 26, 2024

LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial

Shweta Urva, Tamer Coskun, Mei Teng Loh, Yu Du, Melissa K Thomas, Sirel Gurbuz, Axel Haupt, Charles T Benson, Martha Hernandez-Illas, David A D’Alessio, Zvonko Milicevic

Lancet I November 26, 2022

Relative bioavailability and food effect of the galectin‑3 inhibitor selvigaltin (GB1211) administered as a tablet in healthy participants (GALBA‑1)

Vassilios Aslanis, Khalid Abd-Elaziz, Robert J. Slack, Anne Brinch, Lise Gravelle, Wayne Morley, De Phung, Kimberly Herman, Ian Holyer, Karen Killerup Poulsen, Peter Dogterom, Susan Tantawi, Fredrik R. Zetterberg, Brian Jacoby, Hans Schambye & Bertil Lindmark

Cancer Chemotherapy and Pharmacology | 21 August 2024

A Phase 1 First‐in‐Human Single‐Ascending‐Dose Trial With ESB1609, a Selective Agonist to the Sphingosine‐1‐Phosphate Receptor 5

Nicholas P. France, Christopher Rubino, M. Courtney Safir, Mari Maurer, Tram Duong, Deepika Singamsetty, Khalid Abd-Elaziz, Thomas Chou, Sethu Sankaranarayanan, Marieke Ettema, Rebecca Cosford, Peter Dogterom, Enchi Liu, Carrolee Barlow

Clinical Pharmacology in Drug Development – Wiley Online Library | 16 May 2023

Safety, Tolerability, Pharmacokinetics and Initial Pharmacodynamics of a Subcommissural Organ-Spondin-Derived Peptide: A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose First-in-Human Study

Valérie Bourdès, Peter Dogterom, André Aleman, Pierre Parmantier, Damien Colas, Sighild Lemarchant, Sébastien Marie, Thomas Chou, Khalid Abd-Elaziz & Yann Godfrin

Neurology and Therapy | 02 July 2022

Comparison of the Pharmacokinetic Profiles of Trientine Tetrahydrochloride and Trientine Dihydrochloride in Healthy Subjects

Karl Heinz Weiss, Catherine Thompson, Peter Dogterom, Yi-jin Chiou, Tim Morley, Brinley Jackson, Naseem Amin & Camille Omar Farouk Kamlin

European Journal of Drug Metabolism and Pharmacokinetics | 06 August 2021

Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen‐Induced Platelet Aggregation

Lionel Renaud MSc, Kristell Lebozec MSc, Christine Voors-Pette MD, Peter Dogterom PhD, Philippe Billiald PharmD, Martine Jandrot Perrus MD, Yannick Pletan MD, Matthias Machacek PhD

The Journal of Clinical Pharmacology – Wiley Online Library | 04 June 2020

Effect of Rifampin‐Mediated OATP1B1 and OATP1B3 Transporter Inhibition on the Pharmacokinetics of the P2Y12 Receptor Antagonist Selatogrel

Uta Schilling, Jasper Dingemanse, Christine Voors-Pette, Christel Romeijn, Peter Dogterom, Mike Ufer

Clinical and Translational Science – Wiley Online Library | 12 March 2020

 

Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab: First-in-Human Healthy Volunteer Trial

Christine Voors-Pette, Kristell Lebozec, Peter Dogterom, Laurie Jullien, Philippe Billiald, Pauline Ferlan, Lionel Renaud, Olivier Favre-Bulle, Gilles Avenard, Matthias Machacek, Yannick Plétan, and Martine Jandrot-Perrus

Arteriosclerosis, Thrombosis, and Vascular Biology – AHA|ASA Journals | 18 April 2019
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