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Relative bioavailability and food effect of the galectin‑3 inhibitor selvigaltin (GB1211) administered as a tablet in healthy participants (GALBA‑1)

Vassilios Aslanis, Khalid Abd-Elaziz, Robert J. Slack, Anne Brinch, Lise Gravelle, Wayne Morley, De Phung, Kimberly Herman, Ian Holyer, Karen Killerup Poulsen, Peter Dogterom, Susan Tantawi, Fredrik R. Zetterberg, Brian Jacoby, Hans Schambye & Bertil Lindmark

Cancer Chemotherapy and Pharmacology | 21 August 2024

A Phase 1 First‐in‐Human Single‐Ascending‐Dose Trial With ESB1609, a Selective Agonist to the Sphingosine‐1‐Phosphate Receptor 5

Nicholas P. France, Christopher Rubino, M. Courtney Safir, Mari Maurer, Tram Duong, Deepika Singamsetty, Khalid Abd-Elaziz, Thomas Chou, Sethu Sankaranarayanan, Marieke Ettema, Rebecca Cosford, Peter Dogterom, Enchi Liu, Carrolee Barlow

Clinical Pharmacology in Drug Development – Wiley Online Library | 16 May 2023

Safety, Tolerability, Pharmacokinetics and Initial Pharmacodynamics of a Subcommissural Organ-Spondin-Derived Peptide: A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose First-in-Human Study

Valérie Bourdès, Peter Dogterom, André Aleman, Pierre Parmantier, Damien Colas, Sighild Lemarchant, Sébastien Marie, Thomas Chou, Khalid Abd-Elaziz & Yann Godfrin

Neurology and Therapy | 02 July 2022

Comparison of the Pharmacokinetic Profiles of Trientine Tetrahydrochloride and Trientine Dihydrochloride in Healthy Subjects

Karl Heinz Weiss, Catherine Thompson, Peter Dogterom, Yi-jin Chiou, Tim Morley, Brinley Jackson, Naseem Amin & Camille Omar Farouk Kamlin

European Journal of Drug Metabolism and Pharmacokinetics | 06 August 2021

Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen‐Induced Platelet Aggregation

Lionel Renaud MSc, Kristell Lebozec MSc, Christine Voors-Pette MD, Peter Dogterom PhD, Philippe Billiald PharmD, Martine Jandrot Perrus MD, Yannick Pletan MD, Matthias Machacek PhD

The Journal of Clinical Pharmacology – Wiley Online Library | 04 June 2020

Effect of Rifampin‐Mediated OATP1B1 and OATP1B3 Transporter Inhibition on the Pharmacokinetics of the P2Y12 Receptor Antagonist Selatogrel

Uta Schilling, Jasper Dingemanse, Christine Voors-Pette, Christel Romeijn, Peter Dogterom, Mike Ufer

Clinical and Translational Science – Wiley Online Library | 12 March 2020

 

Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab: First-in-Human Healthy Volunteer Trial

Christine Voors-Pette, Kristell Lebozec, Peter Dogterom, Laurie Jullien, Philippe Billiald, Pauline Ferlan, Lionel Renaud, Olivier Favre-Bulle, Gilles Avenard, Matthias Machacek, Yannick Plétan, and Martine Jandrot-Perrus

Arteriosclerosis, Thrombosis, and Vascular Biology – AHA|ASA Journals | 18 April 2019

Gadolinium Presence in Rat Skin: Assessment of Histopathologic Changes Associated with Small Fiber Neuropathy

Boyken J, Lohrke J, Treu A, Neddens J, Jost G, Ulbrich H-F, Balzer T, Frenzel T, Prokesch M, Thuss U, Pietsch H.

Radiology, Vol. 310, No. 1; doi.org/10.1148/radiol.231984

Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation

Adekunle Babalola J, Lang M, George M, Stracke A, Tam-Amersdorfer C, Itxaso I, Lucija D, Tadic J, Schilcher I, Loeffler T, Flunkert S, Prokesch M, Leitinger G, Lass A, Hutter-Paier B, Panzenboeck U, Hoefler G.

Brain Res. 2023 Aug 12:148518. doi: 10.1016/j.brainres.2023.148518. Online ahead of print. PMID: 37579986

Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models

Shirin Sharghi, Stefanie Flunkert, Magdalena Daurer, Roland Rabl, Boris Philippe Chagnaud, Marcello Leopoldo, Enza Lacivita, Birgit Hutter-Paier and Manuela Prokesch.

Front. Neurosci. 17:1087788. 30. March 2023 doi: 0.3389/fnins.2023.1087788

Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease

Vijay R Varma, Rishi J Desai, Sheeja Navakkode, Lik-Wei Wong, Carlos Anerillas, Tina Loeffler, Irene Schilcher, Mufaddal Mahesri, Kristyn Chin, Daniel B Horton, Seoyoung C Kim, Tobias Gerhard, Jodi B Segal, Sebastian Schneeweiss, Myriam Gorospe, Sreedharan Sajikumar, Madhav Thambisetty

Mol Psychiatry. 2022 Dec 28. doi: 10.1038/s41380-022-01912-0.

Leukotriene Signaling as a Target in α-Synucleinopathies

Katharina Strempfl, Michael S. Unger, Stefanie Flunkert, Andrea Trost, Herbert A. Reitsamer, Birgit Hutter-Paier and Ludwig Aigner

Biomolecules. 2022 Feb 23;12(3):346. doi: 10.3390/biom12030346.

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