Spreading Early Clinical Knowledge

Shoulder to shoulder with our clients, we at QPS like to share the results of our early clinical research efforts, published in the scientific literature. Learn more by reading:

A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics-Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose.

Struys MMRF, Valk BI, Eleveld DJ, Absalom AR, Meyer P, Meier S, den Daas I, Chou T, van Amsterdam K, Campagna JA, Sweeney SP.
Anesthesiology. 2017 Jul;127(1):20-35. doi: 10.1097/ALN.0000000000001662.

A new fully human recombinant FSH (follitropin epsilon): two phase I randomized placebo and comparator-controlled pharmacokinetic and pharmacodynamic trials.

Abd-Elaziz K, Duijkers I, Stöckl L, Dietrich B, Klipping C, Eckert K, Goletz S., Hum Reprod. 2017 Aug 1;32(8):1639-1647. doi: 10.1093/humrep/dex220.

Dopamine D2R Agonist-Induced Cardiovascular Effects in Healthy Male Subjects: Potential Implications in Clinical Settings.

Abou Farha K, Baljé-Volkers C, Tamminga W, den Daas I, van Os S.

ISRN Neurol. 2014 Jan 22;2014:956353. doi: 10.1155/2014/956353. eCollection 2014.

Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile.

den Daas I, Wemer J, Abou Farha K, Tamminga W, de Boer T, Spanjersberg R, Struys MM, Absalom AR.

Eur J Clin Pharmacol. 2013 May;69(5):1083-90. doi: 10.1007/s00228-012-1443-y. Epub 2012 Nov 10.

Pharmacokinetics of fingolimod (FTY720) and a combined oral contraceptive coadministered in healthy women: drug-drug interaction study results.

David OJ, Ocwieja M, Meiser K, Emotte C, Jakab A, Wemer J, den Daas I, Schmouder R.

Int J Clin Pharmacol Ther. 2012 Aug;50(8):540-4. doi: 10.5414/CP201675.

Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers.

de Boer T, Wieling J, Meulman E, Reuvers M, Renkema G, den Daas I, van Iersel T, Wemer J, Chen L.
Biomed Chromatogr. 2011 Oct;25(10):1112-23. doi: 10.1002/bmc.1580. Epub 2011 Feb 1.

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